Data deduplication can significantly reduce the amount of disk needed to store your data backups, but things that you do in your data center can actually be working against deduplication. And there are other things that don't necessarily hurt your deduplication system, but aren't a good idea anyway.

This article will explain those things you should (or shouldn't) be doing if you are performing data deduplication.

via searchdatabackup.techtarget.com

http://www.datavaultsecurity.com/TomSims